Upper limits on gravitational wave emission from 78 radio pulsars [Physical Review D - Particles, Fields, Gravitation and Cosmology (2007) 76, (042001)]

This paper was published online on 3 August 2007 with a formatting error in the fifty-first affiliation in the author list.The affiliation should read as ‘‘University of Western Australia, Crawley, WA 6009, Australia.’’ The affiliation has beencorrected as of 4 March 2008. The affiliation is incorrect in the printed version of the journal

Erratum: First cross-correlation analysis of interferometric and resonant-bar gravitational-wave data for stochastic backgrounds (Physical Review D - Particles, Fields, Gravitation and Cosmology (2007) 76, (022001))

This paper was published online on 9 July 2007 with incorrect affiliation numbering in the author list. The affiliations have been corrected as of 23 July 2007. The text is correct in the printed version of the journal

All-sky search for periodic gravitational waves in LIGO S4 data (Physical Review D - Particles, Fields, Gravitation and Cosmology (2008) 77, (022001))

This paper was published online on 10 January 2008 with a formatting error in the forty-ninth affiliation in the author list. The affiliation should read as ‘‘University of Western Australia, Crawley, WA 6009, Australia.’’ The affiliation hasbeen corrected as of 29 February 2008. The affiliation is incorrect in the printed version of the journal

First cross-correlation analysis of interferometric and resonant-bar gravitational-wave data for stochastic backgrounds (Physical Review D - Particles, Fields, Gravitation and Cosmology (2007) 76, (022001))

This paper was published online on 9 July 2007 with a formatting error in the fiftieth affiliation in the author list. Theaffiliation should read as ‘‘University of Western Australia, Crawley, WA 6009, Australia.’’ The affiliation has beencorrected as of 4 March 2008. The affiliation is incorrect in the printed version of the journal

Results of the First Coincident Observations by Two Laser-Interferometric Gravitational Wave Detectors

We report an upper bound on the strain amplitude of gravitational wave bursts in a waveband from around 800Hz to 1.25kHz. In an effective coincident observing period of 62 hours, the prototype laser interferometric gravitational wave detectors of the University of Glasgow and Max Planck Institute for Quantum Optics, have set a limit of 4.9E-16, averaging over wave polarizations and incident directions. This is roughly a factor of 2 worse than the theoretical best limit that the detectors could have set, the excess being due to unmodelled non-Gaussian noise. The experiment has demonstrated the viability of the kind of observations planned for the large-scale interferometers that should be on-line in a few years time.Comment: 11 pages, 2 postscript figure

The status of GEO 600

The GEO 600 laser interferometer with 600m armlength is part of a worldwide network of gravitational wave detectors. GEO 600 is unique in having advanced multiple pendulum suspensions with a monolithic last stage and in employing a signal recycled optical design. This paper describes the recent commissioning of the interferometer and its operation in signal recycled mode

Detector Description and Performance for the First Coincidence Observations between LIGO and GEO

For 17 days in August and September 2002, the LIGO and GEO interferometer gravitational wave detectors were operated in coincidence to produce their first data for scientific analysis. Although the detectors were still far from their design sensitivity levels, the data can be used to place better upper limits on the flux of gravitational waves incident on the earth than previous direct measurements. This paper describes the instruments and the data in some detail, as a companion to analysis papers based on the first data.Comment: 41 pages, 9 figures 17 Sept 03: author list amended, minor editorial change

Search for Gravitational Waves from Primordial Black Hole Binary Coalescences in the Galactic Halo

We use data from the second science run of the LIGO gravitational-wave detectors to search for the gravitational waves from primordial black hole (PBH) binary coalescence with component masses in the range 0.2--$1.0 M_\odot$. The analysis requires a signal to be found in the data from both LIGO observatories, according to a set of coincidence criteria. No inspiral signals were found. Assuming a spherical halo with core radius 5 kpc extending to 50 kpc containing non-spinning black holes with masses in the range 0.2--$1.0 M_\odot$, we place an observational upper limit on the rate of PBH coalescence of 63 per year per Milky Way halo (MWH) with 90% confidence.Comment: 7 pages, 4 figures, to be submitted to Phys. Rev.

A colorectal cancer classification system that associates cellular phenotype and responses to therapy.

Colorectal cancer (CRC) is a major cause of cancer mortality. Whereas some patients respond well to therapy, others do not, and thus more precise, individualized treatment strategies are needed. To that end, we analyzed gene expression profiles from 1,290 CRC tumors using consensus-based unsupervised clustering. The resultant clusters were then associated with therapeutic response data to the epidermal growth factor receptor-targeted drug cetuximab in 80 patients. The results of these studies define six clinically relevant CRC subtypes. Each subtype shares similarities to distinct cell types within the normal colon crypt and shows differing degrees of 'stemness' and Wnt signaling. Subtype-specific gene signatures are proposed to identify these subtypes. Three subtypes have markedly better disease-free survival (DFS) after surgical resection, suggesting these patients might be spared from the adverse effects of chemotherapy when they have localized disease. One of these three subtypes, identified by filamin A expression, does not respond to cetuximab but may respond to cMET receptor tyrosine kinase inhibitors in the metastatic setting. Two other subtypes, with poor and intermediate DFS, associate with improved response to the chemotherapy regimen FOLFIRI in adjuvant or metastatic settings. Development of clinically deployable assays for these subtypes and of subtype-specific therapies may contribute to more effective management of this challenging disease